Potassium canrenoate( Canrenoate potassium | SC 14266 | SC-14266 )

Catalog No. M17721 CAS No. 2181-04-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Potassium canrenoate
Note

Research use only, not for human use.
Brief Description

Potassium canrenoate is a synthetic pregnadiene derivative with anti-aldosterone activity.
Description

Canrenoate potassium is a synthetic pregnadiene derivative with anti-aldosterone activity.(In Vivo):Potassium canrenoate has been shown to cause in rats a dose-dependent increase in myelogenous leukemia and statistically significant increases in malignant tumor of the liver, thyroid, brain and mammary gland.Potassium canrenoate (20 mg/kg/day; drinking water) reduces isoprenaline-induced cardiac fibrosis in the rat.
In Vitro

——
In Vivo

Potassium canrenoate has been shown to cause in rats a dose-dependent increase in myelogenous leukemia and statistically significant increases in malignant tumor of the liver, thyroid, brain and mammary gland.Potassium canrenoate (20 mg/kg/day; drinking water) reduces isoprenaline-induced cardiac fibrosis in the rat.
Synonyms

Canrenoate potassium | SC 14266 | SC-14266
Pathway

GPCR/G Protein
Target

S1P Receptor
Recptor

Mineralocorticoid Receptor
Research Area

Endocrinology
Indication

——

CAS Number

2181-04-6
Formula Weight

396.56
Molecular Formula

C22H29KO4
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 100 mg/mL (252.17 mM)
SMILES

[K+].C(=O)(CC[C@@]1(CC[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4([C@H]3CC[C@]12C)C)O)[O-]
Chemical Name

17-alpha-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, monopotassium salt

1. Alexandre J, et al. J Cardiovasc Pharmacol Ther. 2015 May;20(3):313-21.

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